Vitex agnus-castus dry extract BNO 1095 (Agnucaston®) inhibits uterine hyper-contractions and inflammation in experimental models for primary dysmenorrhea

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Vitex agnus-castus dry extract BNO 1095 (Agnucaston®) inhibits uterine hyper-contractions and inflammation in experimental models for primary dysmenorrhea

Background: For many women, the monthly suffering induced by menstrual “cramps” is severe enough to profoundly disrupt their quality of life. In the case of primary dysmenorrhea, a condition related to premenstrual syndrome (PMS), intense uterine contractions are thought to trigger moderate to intense pain despite the absence of an underlying infection or other medically-identifiable disease st...

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Vitex agnus-castus

Vitex agnus-castus has a long tradition as a herbal remedy and was used in ancient times not only as an anaphrodisiac and for preserving chastity but also against diverse disturbances of the female genital system. In actual clinical trials, the fruit Agni casti fructus was shown to relieve premenstrual syndrome (PMS) and especially breast swelling and pain, due to its dopaminergic effect. Altho...

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Vitex agnus-castus L. (chaste-berry). Phytomedicine. 2004 Jan;11(1):18-23. Liu J, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR. Department of Medicinal Chemistry and Pharmacognosy, UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illi...

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Comparison of Vitex agnus castus Extract and Pergolide in Treatment of Equine Cushing's Syndrome

Pituitary pars intermedia hyperplasia, which causes Equine Cushing’s Syndrome, has been treated with dopaminergic agonists such as pergolide. Vitex agnus castus (Chaste Berry) extract has been used medicinally for centuries for various human female cycle disorders, and a lay article claimed its therapeutic efficacy in horses with pituitary hyperplasia and other hormonal dysfunction. Ethanol ext...

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Vitex agnus castus L. (VAC) [Verbenaceae] is a deciduous shrub that is native to Mediterranean Europe and Central Asia. Traditionally, VAC fruit extract has been used in the treatment of many female conditions, including menstrual disorders (amenorrhoea, dysmenorrhoea), premenstrual syndrome (PMS), corpus luteum insufficiency, hyperprolactinaemia, infertility, acne, menopause and disrupted lact...

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ژورنال

عنوان ژورنال: Clinical Phytoscience

سال: 2016

ISSN: 2199-1197

DOI: 10.1186/s40816-016-0034-3